Preparation and characterization of pH-responsive ionic crosslinked microparticles of mercaptopurine to target ulcerative colitis

The objective of this study was the preparation ionically crosslinked 6-mercaptopurine (6-MP) monohydrate microparticles through preparing polyelectrolyte complexes drug and polymers. Polymers such as chitosan, casein, carrageenan were used to prepare microparticles, sodium tripolyphosphate crosslinker. Microparticles characterized for their flow behavior, compressibility, percentage yield, micromeritic, entrapment efficiency. Scanning electron microscopy conducted understand surface morphology result correlated with swelling index release. Mathematical modeling release in order determine kinetics also determined mechanism involving from microparticles. ionic range 664 μm–798 μm particle size having good compressibility properties yield found be 77.5% 87.5% range. efficiency formulations 63.5% 83.5%, MCP-5 gave maximum 83.5%. In vitro studies accordance polymer following zero-order model super-case transport II.